{"id":3479,"date":"2021-04-14T10:25:46","date_gmt":"2021-04-14T10:25:46","guid":{"rendered":"https:\/\/medfiz.si\/kvantitativni-slikovni-biomarkerji-nevrodegenerativnih-bolezni-mozganov"},"modified":"2021-11-24T11:52:09","modified_gmt":"2021-11-24T11:52:09","slug":"kvantitativni-slikovni-biomarkerji-nevrodegenerativnih-bolezni-mozganov","status":"publish","type":"page","link":"https:\/\/medfiz.si\/en\/kvantitativni-slikovni-biomarkerji-nevrodegenerativnih-bolezni-mozganov","title":{"rendered":"Quantitative imaging biomarkers of neurodegenerative brain disorders"},"content":{"rendered":"\n\t<section class=\"section\" id=\"section_1608092474\">\n\t\t<div class=\"section-bg fill\" >\n\t\t\t\t\t\t\t\t\t\n\t\t\t\n\n\t\t<\/div>\n\n\t\t\n\n\t\t<div class=\"section-content relative\">\n\t\t\t\n<div class=\"row\"  id=\"row-1055302294\">\n\n\t<div id=\"col-551940393\" class=\"col medium-8 small-8 large-8\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h1 style=\"text-align: left;\"><span style=\"font-size: 120%; color: #ffffff;\">Quantitative imaging biomarkers of neurodegenerative brain disorders<\/span><\/h1>\n<div class=\"is-divider divider clearfix\" style=\"max-width:58px;background-color:rgb(255, 255, 255);\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-1249521473\" class=\"col medium-4 small-4 large-4\"  >\n\t\t\t\t<div class=\"col-inner text-right\"  >\n\t\t\t\n\t\t\t\n\t<div class=\"img has-hover x md-x lg-x y md-y lg-y\" id=\"image_813877628\">\n\t\t\t\t\t\t\t\t<div class=\"img-inner dark\" >\n\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"256\" height=\"256\" src=\"https:\/\/medfiz.si\/wp-content\/uploads\/2021\/03\/imaging.png\" class=\"attachment-large size-large\" alt=\"\" \/>\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\n<style>\n#image_813877628 {\n  width: 50%;\n}\n@media (min-width:550px) {\n  #image_813877628 {\n    width: 23%;\n  }\n}\n<\/style>\n\t<\/div>\n\t\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n<\/div>\n<div class=\"row align-middle align-center\"  id=\"row-1777308805\">\n\n\t<div id=\"col-1778637735\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<div class=\"row\"  id=\"row-1131210088\">\n\n\t<div id=\"col-1349560800\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<p style=\"color: #fff;\">We found that Parkinson\u2019s disease-related pattern (PDRP) can differentiate well between patients with Parkinson\u2019s disease, healthy volunteers, and patients with atypical parkinsonian syndromes. We have shown that PDRP was highly reproducible across different image reconstruction algorithms, contributing to the broader use of such biomarkers. In dementia with Lewy bodies, we identified brain regions whose impairment contributes to clinical features [5881260]. We explored the role of genetics in the dopaminergic treatment of Parkinson\u2019s disease (PD). We found out that inflammation and oxidative stress gene variabilities do not play a significant role in the occurrence of PD and the adverse events to such treatment. In a study of the quality-of-life outcomes in Parkinson\u2019s disease patients undergoing different therapies, we identified distinct effect profiles of bilateral subthalamic stimulation, apomorphine, and intrajejunal levodopa infusion. We highlighted the importance of holistic symptoms assessments to personalize the treatment choices. We participated in international initiatives aimed at developing biomarkers of neurodegenerative brain disorders (IAEA CR E13043, DUOGLOBE grants). We have established the importance of harmonizing FDG PET brain imaging in neurology, specifically for Parkinson\u2019s disease (PETMETPAT, JPCOFUND_FP-940-010 grants).<\/p>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n<\/div>\n\t\t<\/div>\n\n\t\t\n<style>\n#section_1608092474 {\n  padding-top: 30px;\n  padding-bottom: 30px;\n  background-color: rgb(59, 141, 164);\n}\n<\/style>\n\t<\/section>\n\t\n\n\t<section class=\"section\" id=\"section_1766746598\">\n\t\t<div class=\"section-bg fill\" >\n\t\t\t\t\t\t\t\t\t\n\t\t\t\n\n\t\t<\/div>\n\n\t\t\n\n\t\t<div class=\"section-content relative\">\n\t\t\t\n<div class=\"row\"  id=\"row-944142273\">\n\n\t<div id=\"col-954678482\" class=\"col medium-8 small-8 large-8\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<h1 style=\"text-align: left;\"><span style=\"font-size: 120%; color: #ffffff;\">Projects<\/span><\/h1>\n<div class=\"is-divider divider clearfix\" style=\"max-width:58px;background-color:rgb(255, 255, 255);\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-1052124996\" class=\"col medium-4 small-4 large-4\"  >\n\t\t\t\t<div class=\"col-inner text-right\"  >\n\t\t\t\n\t\t\t\n\t<div class=\"img has-hover x md-x lg-x y md-y lg-y\" id=\"image_2000319986\">\n\t\t\t\t\t\t\t\t<div class=\"img-inner dark\" >\n\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"256\" height=\"256\" src=\"https:\/\/medfiz.si\/wp-content\/uploads\/2021\/03\/imaging.png\" class=\"attachment-large size-large\" alt=\"\" \/>\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\n<style>\n#image_2000319986 {\n  width: 50%;\n}\n@media (min-width:550px) {\n  #image_2000319986 {\n    width: 23%;\n  }\n}\n<\/style>\n\t<\/div>\n\t\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n<\/div>\n<div class=\"row align-middle align-center\"  id=\"row-576764100\">\n\n\t<div id=\"col-780085814\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<div class=\"tabela\">\n<div class=\"vrstica-projekti prva-vrstica\">\n<div class=\"skrij-mobilc cetrtina dimenzije center stolpec\">Project ID<\/div>\n<div class=\"skrij-mobilc cetrtina dimenzije center stolpec\">Researcher<\/div>\n<div class=\"skrij-mobilc cetrtina dimenzije center stolpec\">Title<\/div>\n<div class=\"skrij-mobilc cetrtina dimenzije center stolpec\">Duration<\/div>\n<\/div>\n<div class=\"vrstica-projekti\">\n<div class=\"cetrtina dimenzije stolpec cetrta-projekti\">J7-3150<\/div>\n<div class=\"cetrtina dimenzije stolpec prva-projekti\">Simoncic U<\/div>\n<div class=\"cetrtina dimenzije stolpec druga-projekti\"><a href=\"https:\/\/bit.ly\/30QcWSL\">Computer-aided differential diagnosis of parkinsonism based on FDG-PET imaging<\/a><\/div>\n<div class=\"cetrtina dimenzije stolpec tretja-projekti\">2021-2024<\/div>\n<\/div>\n<div class=\"vrstica-projekti\">\n<div class=\"cetrtina dimenzije stolpec cetrta-projekti\">J7-2600<\/div>\n<div class=\"cetrtina dimenzije stolpec prva-projekti\">Tro\u0161t M<\/div>\n<div class=\"cetrtina dimenzije stolpec druga-projekti\"><a href=\"https:\/\/bit.ly\/30X1HHP\/\">Metabolic brain characteristics in neurodegenerative dementia syndromes and its correlation with histopathological brain changes<\/a><\/div>\n<div class=\"cetrtina dimenzije stolpec tretja-projekti\">2020-2023<\/div>\n<\/div>\n<div class=\"vrstica-projekti\">\n<div class=\"cetrtina dimenzije stolpec cetrta-projekti\">IAEA CR E13043<\/div>\n<div class=\"cetrtina dimenzije stolpec prva-projekti\">Tro\u0161t M<\/div>\n<div class=\"cetrtina dimenzije stolpec druga-projekti\"><a href=\"https:\/\/bit.ly\/32k7o32\">Enhancing Capacity of Neuroimaging and Biomarkers: Application in Early-stage Alzheimer\u2019s Disease with Comorbidities<\/a><\/div>\n<div class=\"cetrtina dimenzije stolpec tretja-projekti\">2015-2021<\/div>\n<\/div>\n<div class=\"vrstica-projekti\">\n<div class=\"cetrtina dimenzije stolpec cetrta-projekti\">DUOGLOBE<\/div>\n<div class=\"cetrtina dimenzije stolpec prva-projekti\">Tro\u0161t M<\/div>\n<div class=\"cetrtina dimenzije stolpec druga-projekti\"><a href=\"https:\/\/bit.ly\/3CGXogU\">Observational Study Evaluating Long-Term Effectiveness of Duodopa\/Duopa in Patients With Advanced Parkinson&#8217;s Disease<\/a><\/div>\n<div class=\"cetrtina dimenzije stolpec tretja-projekti\">2015-2021<\/div>\n<\/div>\n<div class=\"vrstica-projekti\">\n<div class=\"cetrtina dimenzije stolpec cetrta-projekti\">PETMETPAT<\/div>\n<div class=\"cetrtina dimenzije stolpec prva-projekti\">Tro\u0161t M<\/div>\n<div class=\"cetrtina dimenzije stolpec druga-projekti\"><a href=\"https:\/\/bit.ly\/3CPc1i2\">Harmonisation metabolic FDG brain pattern characteristics<\/a><\/div>\n<div class=\"cetrtina dimenzije stolpec tretja-projekti\">2017-2018<\/div>\n<\/div>\n<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-1377391104\" class=\"col medium-3 small-12 large-3\"  >\n\t\t\t\t<div class=\"col-inner text-center\"  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